Encapsulation of adriamycin in human erythrocytes.
نویسندگان
چکیده
منابع مشابه
Adriamycin and Daunomycin Generate Reactive 0 xygen Compounds in Erythrocytes
Adriamycin and daunomycin produce glutathione, by ‘4C-formate oxidation, dose-related cardiac toxicity that may be and by the catalase-aminotriazole trapping related to oxygen radicals. Addition of technique. These experiments indicate these compounds to human erythrocyte that Adriamycin and daunomycin interact suspensions resulted in stimulation of with oxyhemoglobin to generate reactive hexos...
متن کاملAdriamycin and daunomycin generate reactive oxygen compounds in erythrocytes.
Adriamycin and daunomycin produce dose-related cardiac toxicity that may be related to oxygen radicals. Addition of these compounds to human erythrocyte suspensions resulted in stimulation of hexose monophosphate shunt activity that was markedly impaired in the absence of oxyhemoglobin. Evidence for generation of hydrogen peroxide by these compounds was provided by oxidation of reduced glutathi...
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Vectamidine is a liposome-forming double-chain cationic amphiphile. The present work was aimed to microscopically study the interactions of Vectamidine liposomes with the human erythrocyte plasma membrane. Vectamidine rapidly induced stomatocytic shapes. Attachment of Vectamidine liposomes to the erythrocyte induced a strong local invagination of the membrane. This frequently resulted in a comp...
متن کاملEffects of Pravastatin in Adriamycin-Induced Nephropathy in Rats
The aim of this study is to evaluate the effects of pravastatin on Adriamycin (ADR)-induced nephropathy and the mechanisms involved. Forty rats were divided into the following 4 groups: control, ADR (15 mg.kg-1, IP), ADR plus pravastatin (20 mg.kg-1 which was started 5 days prior to ADR injection), and ADR plus pravastatin (20 mg.kg-1 which was started 5 days after ADR injection). On day 20 aft...
متن کاملAdriamycin induces H2AX phosphorylation in human spermatozoa.
AIM To investigate whether adriamycin induces DNA damage and the formation of gammaH2AX (the phosphorylated form of histone H2AX) foci in mature spermatozoa. METHODS Human spermatozoa were treated with adriamycin at different concentrations. gammaH2AX was analyzed by immunofluorescent staining and flow cytometry and double-strand breaks (DSB) were detected by the comet assay. RESULTS The ne...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1986
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.83.18.7029